So simple, so elegant, and so useful.Īnother note – you might notice that the base here (CH 3O –) is a stronger base than we see for the E1 reaction (more on that later). I can’t even begin to stress how important this data can be in understanding reaction mechanisms. That means that whatever mechanism we propose for this reaction has to explain this data.īy the way, see how useful chemical kinetics can be? They’re such simple experiments – measure reaction rate versus concentration – and you get these nice graphs out of it. It’s dependent on the concentration of both substrate and the base. Well, when we look at the rate law for this reaction, we find that it depends on two factors. Remember that the E1 reaction has a “unimolecular” rate determining step (that is, the rate only depends on the concentration of the substrate?) Clue #1 About The Mechanism Of The E2 Reaction: The Rate Depends on Concentration of Both Substrate and Base We’ll talk about two key differences here. What’s interesting about this reaction is that it doesn’t follow the same rules that we saw for the E1 reaction. Here’s an example of the reaction I’m talking about: Example Of An “E2” Reaction: How Do We Explain What Happens In This Reaction?
Clue #2 About The Mechanism Of The E2 Reaction: Stereochemistry Of The C–H Bond And The Leaving Group Is Always “Anti”.Clue #1 About The Mechanism Of The E2 Reaction: The Rate Depends on Concentration of Both Substrate and Base.Example Of An “E2” Reaction: How Do We Explain What Happens In This Reaction?.However, there’s still another set of data that describes some elimination reactions that we haven’t adequately explained yet. Having gone through the E1 mechanism for elimination reactions, we’ve accounted for one way in which elimination reactions can occur.
E2 Mechanism – How The E2 (Elimination, Biomolecular) Reaction Works
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